Prescription drug spending in the United States continues to rise sharply. According to a new report from the American Society of Health-System Pharmacists (ASHP) , U.S. prescription drug spending reached nearly $806 billion in 2024 (an increase of 10.2% compared to 2023). [Download the full PDF report] The main driver behind this growth? Medications, used to treat diabetes and obesity, have seen rapid adoption and high utilization across many populations. In 2025, several factors continue to impact prescription drug spending: Tariffs on pharmaceutical ingredients , especially those sourced from China, may lead to shortages and drive patients toward more expensive brand-name medications. Oncology drug spending is expected to grow as new high-cost treatments enter the market and the use of existing therapies expands. Vaccine spending has declined post-pandemic , but reduced vaccination rates may contribute to rising costs in other areas of care...